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மீனாட்சியம்மன் கோயில் குடமுழுக்கு; பக்தர்கள் மீது தெளிக்கப்பட்ட புனித நீர்
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Alcohol withdrawal explained simply: GABA and glutamate balance
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GABA!!! Two big distinctions here— positive allosteric modulators (benzos) vs direct agonists (anesthetics like propofol or alfaxalone). Disinhibitions occurs because downstream neurons are not receiving inhibitory signals anymore (because that presynaptic neuron is inhibited by our drug while normally it releases GABA to calm downstream neurons). neuropharm is so juicy. #fyp #gaba #vetmed
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TikTokbexie
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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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